What Does Isotretinoin Do to Your Body?

Isotretinoin 20mg , commonly known by brand names such as Accutane, Claravis, and Roaccutane, is a powerful oral medication primarily prescribed for severe or treatment-resistant acne. Though highly effective, isotretinoin has a profound impact on the body and is often surrounded by questions and caution due to its potent effects and potential side effects.

In this article, we’ll explore what isotretinoin actually does to your body—how it works, what changes you might experience during treatment, and the short-term and long-term implications for your skin and health.

What Is Isotretinoin?

Isotretinoin is a retinoid, a derivative of vitamin A. It’s used to treat severe nodular acne, cystic acne, or acne that hasn't responded to other treatments like antibiotics or topical creams.

Unlike creams or gels applied to the skin, isotretinoin is taken orally, and it works systemically—affecting the entire body. That’s why its effects are wide-ranging and not just limited to the skin. You can also buy isotretinoin online from dosepharmacy. 

How Does Isotretinoin Work in the Body?

1. Shrinks Sebaceous Glands

Isotretinoin significantly reduces the size and activity of the sebaceous (oil) glands in the skin. These glands produce sebum, an oily substance that can clog pores and contribute to acne.

By shrinking these glands, isotretinoin drastically reduces oil production, making the skin less oily and less prone to breakouts.

2. Prevents Clogged Pores

It normalizes the shedding of dead skin cells inside the hair follicles. In people with acne, these cells shed irregularly and stick together, leading to clogged pores and breakouts.

Isotretinoin helps regulate this process, preventing the formation of blackheads and whiteheads.

3. Kills Acne-Causing Bacteria

While isotretinoin doesn’t act like a traditional antibiotic, it still creates an environment where Cutibacterium acnes (the bacteria that cause acne) cannot thrive. Less oil and cleaner pores mean less food and space for these bacteria.

4. Reduces Inflammation

It also has anti-inflammatory properties, helping to calm red, swollen acne lesions and prevent scarring.

What Physical Changes Happen During Treatment?

Skin and Hair

• Dry skin is the most common side effect.

• Lips become dry and cracked (cheilitis).

• Nosebleeds may occur due to dryness in nasal passages.

• Some users experience dry or irritated eyes.

• Hair may become thinner or drier, though hair loss is uncommon and typically reversible.

Mood and Mental Health

There has been debate over isotretinoin’s impact on mental health, including mood changes or depression. While some studies suggest a link, others find no clear correlation. Doctors now screen patients for mood disorders before and during treatment to ensure safety.

 Muscle and Joint Pain

Some users experience muscle stiffness, joint pain, or back pain, especially those who are physically active. This is usually mild but should be monitored.

Vision Changes

Because it affects vitamin A pathways, isotretinoin may cause night vision difficulties or dry eyes. Users are often advised to avoid driving at night if this becomes noticeable.

Impact on Organs and Systems

Liver Function

Isotretinoin is metabolized in the liver, so it can elevate liver enzymes and cholesterol levels during treatment. Doctors typically monitor liver function through blood tests before, during, and after the course.

 Lipid Profile

Triglyceride levels can rise while on isotretinoin, increasing cardiovascular risk if not monitored. Diet and dosage adjustments can help control this.

Reproductive System

This is perhaps the most critical area of concern.

Isotretinoin is highly teratogenic, meaning it can cause severe birth defects if taken during pregnancy. Because of this, patients who can become pregnant must:

• Use two forms of birth control

• Have monthly pregnancy tests

• Enroll in a pregnancy prevention program (iPLEDGE in the U.S.)

These steps are non-negotiable and are enforced to avoid even the slightest risk of fetal exposure.

Long-Term Effects

For most users, the effects of isotretinoin wear off after treatment ends, and long-term side effects are rare. However, some individuals report:

• Chronic dry skin or lips

• Lingering joint pain

• Persistent vision issues

• Gastrointestinal changes, possibly linked to conditions like inflammatory bowel disease (though data is inconclusive)

Fortunately, the majority of patients tolerate isotretinoin well and enjoy long-lasting clear skin after just one course, with no permanent side effects.

Safety Measures and Monitoring

Due to its potency, isotretinoin treatment is closely monitored:

✅ Before Starting:

• Complete blood work (liver, kidney, lipid profile)

• Pregnancy test (if applicable)

• Review medical history and current medications

✅ During Treatment:

• Monthly follow-ups

• Blood tests every 1–2 months

• Mental health check-ins

• Pregnancy tests and contraceptive counseling

✅ After Treatment:

• Skin continues to improve for up to 6 months

• Patients may be advised to wait before starting procedures like waxing or laser treatments, as skin remains sensitive

Who Should Avoid Isotretinoin?

Isotretinoin may not be suitable for:

• Pregnant or breastfeeding individuals

• People with liver disease

• Individuals with uncontrolled high cholesterol

• Those with a history of severe depression or mental illness (should be evaluated by a doctor)

Always disclose your full medical history before starting isotretinoin.

Tips to Cope With Side Effects

• Stay hydrated: Drink plenty of water and use moisturizers.

• Use lip balm frequently.

• Wear sunscreen: Skin becomes more sun-sensitive.

• Avoid harsh skincare products, especially those containing alcohol, benzoyl peroxide, or salicylic acid.

• Report any unusual symptoms to your doctor immediately.

Conclusion: What Does Isotretinoin Do to Your Body?

Isotretinoin is a powerful, life-changing medication for those struggling with severe acne. It works deeply within the body—reducing oil production, clearing pores, calming inflammation, and minimizing acne-causing bacteria.

While it carries risks and requires strict monitoring, most patients experience dramatic improvement in skin clarity and self-confidence after treatment.

Understanding what isotretinoin does to your body helps you prepare, monitor side effects, and get the most benefit from the treatment—safely and effectively.